Main Page » Produkty dla ludzi » HopXn +Curcumin Throat spray

Unique invention on a global scale by Professor M. Gagoś.

Original, unique and the only preparation in the world which protects bees against the effects of neonicotinoids and toxins.

VITAEAPIS® acts as protection and removes neonicotinoids from the bees' nervous system. This triggers a cascade of effects leading to an increase in the behavioural resistance of the bee colony (more in the PRODUCT DESCRIPTION tab).

The product is covered by Polish and European patent protection.

Patent owner - BioActive-Tech Sp. z o.o.


Advantages of Vitaeapis®:

- ingredients of natural origin
- possibility of application during honey harvest
- easy application by dissolving in sugar syrup (the mixture should be sprayed into inter-frame lanes or sprayed on the bees on frames or poured into the feeders)
HopXn +Curcumin Throat spray
New

HopXn +Curcumin Throat spray


More information: info@vitaeapis-new.com

  • Product description

Throat spray - Effective protection against pathogens


The medicinal product HopXn+Curcumin
  • Forms an active barrier on the pharyngeal and laryngeal mucosa preventing penetration by viruses, bacteria, and fungi
  • Has a synergistically active composition of hop flavonoids, including xanthohumol, curcumin, and curcuminoids exerting strong antioxidant and anti-inflammatory effects
  • Supports wound healing and regeneration
  • Moisturizes the throat and larynx
  • Has a water-soluble composition ensuring effective absorption of active ingredients

The anti-inflammatory, antimicrobial, and antioxidant effects of HopXn+Curcumin Spray ingredients have been confirmed by scientific research. The upper respiratory tract is the gateway for viruses, including SARS-CoV-2, into the organism. The HopXn+Curcumin spray forms an active barrier on the throat and larynx mucosa preventing penetration of viruses, bacteria, and fungi into the organism. The natural plant-origin ingredients of HopXn+Curcumin ensure safety of application of the product several times a day. Importantly, even a safe formulation may trigger allergic reactions, especially in allergy sufferers.

Xanthohumol (Xn)
Common hops (Humulus lupulu s L.) contain approximately 130 different substances, including bitter acids, polyphenols, essential oils, monosaccharides, amino acids, proteins, lipids, fatty acids, pectins, salts, lignins, and other compounds. The polyphenolic compounds present in hops at an average level of 3-5% are represented by flavonoids.
The dominant flavonoid in hops is xanthohumol, which constitutes approximately 90% of all prenylated flavonoids, i.e. the so-called chalcones, in this plant. Its content in hop cones is approx. 1% of dry matter. Xanthohumol is contained in female inflorescences.
The extraction of natural xanthohumol from hops is a long-term process requmng specialist knowledge. Based on the expertise of a Professor of biological sciences, BioActive­ Tech Ltd. has developed an extremely efficient original method for extraction of xanthohumol with high pharmaceutical purity (http://xanthohumol.com.pl/). In the next stage of the investigations, the Professor designed the HopXn+Curcumin Throat Spray with high antimicrobial and anti-inflammatory effectiveness ensured by the synergistic effect of xanthohumol, curcumin, and curcuminoids.

Curcumin (Cur)
Another chalcone, 1.e. curcumm with its derivatives called curcuminoids, is an ingredient of XopXn+Curcumin. Curcumin is a natural polyphenolic compound obtained from Curcuma longa rhizomes.
Similar to xanthohumol, it exhibits a number of therapeutic properties, e.g. antioxidant, antibacterial, anti-proliferative, anti-inflammatory, neuroprotective, and cardioprotective activities.
Curcuminoids, i.e. the most active ingredients in turmeric, are polyphenols with structural similarity to curcumin and very strong antioxidant activity responsible for the health­ enhancing properties of turmeric. As shown by the latest research, they increase the bioavailability and activity of curcumin.

Literature
1. Stevens, J.F., Page, J. E., Xanthohumol and related prenyljlavonoids from hops and beer: to your good health! Phytochemistry, 2004. 65(10): p. 1317-30.
2. Stompor, M. and B. Zarowska, Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues. Molecules, 2016. 21(5).
3. Lee, LS., et al., Anti-iriflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells. Neurochem Int, 2011. 58(2): p. 153-60.
4. Caplin, M., Luohai, L., The Potential Role of Xanthohumol in SARS-CoV -2 Treatment- Globally Accessible and Economically Viable. Nutrition and Dietary Supplements 2020. 12: p. 201-204.
5. Zhang, H., et al., Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med, 2020. 46(4): p. 586-590.
6. Jia, H.P., et al., ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol, 2005. 79(23): p. 14614-21.
7. Zhang, N., et al., A new formylated cha/cone from Humulus lupulus with protective effect on HUVECs injury by angiotensin II Nat Prod Res, 2019. 33(5): p. 617-621.
8. Liu, X., et al., Therapeutic effect of Xanthohumol against highly pathogenic porcine reproductive and respirato,y syndrome viruses. Vet Microbial, 2019. 238: p. 108431.
9. Amalraj, A., et al., Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives -A review. J Tradit Complement Med, 2017. 7(2): p. 205- 233.
10. Zahedipour, F., et al., Potential effects of curcumin in the treatment of COVID-19 infection. Phytother Res, 2020. 34(11): p. 2911-2920.
11. Vivek Kumar Soni. et al., Curcumin, a traditional spice component, can hold the promise against COVID-19? European Journal of Pharmacology, 2020. 886(173551).
12. Sikora, E., G. Scapagnini, andM. Barbagallo, Curcumin, inflammation, ageing and age­ related diseases. Immun Ageing, 2010. 7(1): p. 1.